St Luke’s Institute of Cancer Research

St Luke’s Institute of Cancer Research was set up in 1992. The Clinical Trials Resource Unit was established in 2002 by St Luke’s Institute of Cancer Research to strive to introduce the latest technologies and techniques for the benefit of patients and to do so on a basis of sound evidence, focusing on radiation oncology.

St Luke’s Institute of Cancer Research is supporting radiation therapy based research and allied research across the three centres of St Luke’s Radiation Oncology Network. Each year, The Friends of St Luke’s provide a research grant for clinical based cancer research carried out across the St Luke’s Network.

The main objectives of the Institute are

  • To fulfil the research role of the Network.
  • To support research across a broad spectrum of clinical practice including therapeutic, diagnostic and laboratory work.
  • To foster an environment for the training of young cancer researchers.
  • To develop and encourage relationships through collaborative work with other academic and research institutes.
  • To support post graduate fellowships specialising in cancer treatment.


The Clinical Trials Resource Unit (CTRU) is available to support all approved clinical trials taking place in St. Luke’s Network. It provides some core administrative services including data management and statistical support and also the maintenance of the Oncology Resource Centre at Rathgar.

Director: Prof Sinead Brennan, Consultant Radiation Oncologist.

The Clinical Trials Resource Unit also provides office space for trial development, management, publication preparation, etc. This can be booked, as required.

Our current portfolio includes trials in prostate, lung, spinal cord compression, head and neck, and breast cancer areas. We also have some translational studies in progress.

Prostate Trials

A randomised trial comparing the bladder volume consistency achieved with two bladder-filling protocols in prostate conformal radiotherapy. ICORG 05-04.
A prospective phase II dose escalation trial using IMRT and IGRT for T1a-T3c, N0, M0 prostate cancer. ICORG 08-17.
CHHiP Conventional or hypofractionated high dose intensity modulated radiotherapy prostate cancer. ICORG 08-18.

Lung Trials

Radiation dose escalation for non-small cell lung cancer using hypofractionated 3-dimensional conformal radiation therapy. ICORG 99-09.
Prospective evaluation of PET-CT scan in patients with non-operable or non-resectable NSCLC treated by radical 3-DCRT. ICORG 06-35.
A clinical trial using 3-DCRT to reduce the toxicity of palliative radiation for lung cancer. ICORG 06-34.
Spinal Cord Compression Trials
A randomised phase III trial of two fractionation schemes in the treatment of malignant spinal cord compression. ICORG 05-03.
A phase II trial evaluating the efficacy of a radio-biological based re-irradiation strategy for patients with malignant spinal cord compression. ICORG 07-11.

Head and Neck Trials

A prospective randomised controlled clinical trial to evaluate standard versus customised headrests for head and neck radiotherapy patients. ICORG 08-09.

Breast Trials

Phase II randomised clinical trial of accelerated partial breast irradiation (APBI) comparing 3-dimensional conformal radiation therapy and multi-catheter interstitial brachytherapy. ICORG 06-33.
NSABP B-39. A randomised phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) for women with stage 0, I or II breast cancer. ICORG 08-06.

Translational Studies

Proteomic analysis of combined hormonal therapy and radiation therapy of intermediate risk localised prostate cancer.ICORG 06-15.
Collaborative project on potential serum markers for malignant melanoma, metastatic breast, advanced lung, pancreatic carcinoma and colorectal cancer. ICORG 07-12.


St. Luke’s Institute of Cancer Research
Highfield Road, Rathgar, Dublin 6. Tel. (01) 496 0852. Fax. (01) 497 4886. Email.

Director of Research: Prof Sinead Brennan